HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 3-(3,5-difluoro-4-hydroxyphenyl)propanoate → HCID 74222281, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 3-(3,5-difluoro-4-hydroxyphenyl)propanoate | HCID 23136305 | — |
| Reactant | 2-Butylsulfanyl-3-chloromethyl-pyridine | HCID 90118254 | — |
| Product | HCID 74222281 | HCID 74222281 | 76% |
Reaction Steps
3-Chloromethyl-2-ethylsulfanyl-pyridine (0.1 g, 0.53 mmol) obtained in Step C of Preparation Example 11 and 3-(3,5-difluoro-4-hydroxy-phenyl)-propionic acid ethyl ester (0.12 g, 0.53 mmol) obtained in Step D of Preparation Example 2 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (76% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09447044B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-d8ceb9879ce342de806ce711e0c7be7b |
| Source note | uspto-grants-2016_09 |