(Pyridin-4-yl)boronic acid → HCID 52936846, compound

HRID 629265Notes

Reaction equation

HRID 629265 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8](I)=[CH:9][N:10]=2)[CH:7]=1.[N:12]1[CH:17]=[CH:16][C:15](B(O)O)=[CH:14][CH:13]=1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([C:15]3[CH:16]=[CH:17][N:12]=[CH:13][CH:14]=3)=[CH:9][N:10]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 2734379(Pyridin-4-yl)boronic acidHCID 220316326-Bromo-3-iodoimidazo(1,2-a)pyridine

Product 1

HCID 52936846HCID 52936846, compound

Procedure

The title compound, off-white solid (0.27 g, 45%), MS (ISP) m/z=274.4 [(M+H)+], mp 134° C., was prepared in accordance with the general method of intermediate E from commercially available 6-bromo-3-iodoimidazo[1,2-a]pyridine (0.7 g, 2.17 mmol) and commercially available pyridine-4-ylboronic acid (0.27 g, 2.17 mmol).

Sources & evidence

ORD record
ord-2974daefb9344fa09e202f2c11e5b554
Source dataset
uspto-grants-2016_04
Patent number
US09315502B2

Reaction notes

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