6-Bromo-3-(4-fluorophenyl)-imidazo[1,2-a]pyridine → 6-[2-(4-Chloro-phenyl)-2H-pyrazol-3-yl]-3-(4-fluoro-phenyl)-imidazo[1,2-a]pyridine

Participants

Reaction Steps

The title compound, white solid (27 mg, 20%), MS (ISP) m/z=389.4 [(M+H)+], mp 147° C., was prepared in accordance with the general method of example 1 from 6-bromo-3-(4-fluoro-phenyl)-imidazo[1,2-a]pyridine (intermediate E) (0.1 mg, 0.34 mmol) and 1-(4-chloro-phenyl)-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole (intermediate B) (0.13 g, 0.41 mmol).

Provenance & Evidence