6-Bromo-3-(2,4-difluoro-phenyl)-imidazo[1,2-a]pyridine → 6-[2-(4-Chloro-phenyl)-2H-pyrazol-3-yl]-3-(2,4-difluoro-phenyl)-imidazo[1,2-a]pyridine

Participants

Reaction Steps

The title compound, white solid (40 mg, 30%), MS (ISP) m/z=407.4 [(M+H)+], mp 152° C., was prepared in accordance with the general method of example 1 from 6-bromo-3-(2,4-difluoro-phenyl)-imidazo[1,2-a]pyridine (intermediate K) (0.1 g, 0.324 mmol) and 1-(4-chloro-phenyl)-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole (intermediate B) (0.12 g, 0.39 mmol).

Provenance & Evidence