1-(4-chlorophenyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole → 6-[2-(4-Chloro-phenyl)-2H-pyrazol-3-yl]-3-(4-trifluoromethyl-phenyl)-imidazo[1,2-a]pyridine

Participants

Reaction Steps

The title compound, off-white solid (72 mg, 56%), MS (ISP) m/z=439.5 [(M+H)+], mp 167° C., was prepared in accordance with the general method of example 1 from 6-bromo-3-(4-trifluoromethyl-phenyl)-imidazo[1,2-a]pyridine (intermediate M) (0.1 g, 0.29 mmol) and 1-(4-chloro-phenyl)-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole (intermediate B) (0.12 g, 0.38 mmol).

Provenance & Evidence