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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 62929Generated: October 25, 2026

3-Chloromethyl-2-phenylsulfanyl-pyridine → 3-[3,5-Difluoro-4-(2-phenylsulfanyl-pyridin-3-ylmethoxy)-phenyl]-propionic acid

https://huagongshe.com/reaction/62929

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Chloromethyl-2-phenylsulfanyl-pyridineHCID 19261865—
ReactantEthyl 3-(3,5-difluoro-4-hydroxyphenyl)propanoateHCID 23136305—
Product3-[3,5-Difluoro-4-(2-phenylsulfanyl-pyridin-3-ylmethoxy)-phenyl]-propionic acidHCID 7422228651%

Reaction Steps

3-Chloromethyl-2-phenylsulfanyl-pyridine obtained in Step C of Preparation Example 15 and 3-(3,5-difluoro-4-hydroxy-phenyl)-propionic acid ethyl ester (21 mg, 0.09 mmol) obtained in Step D of Preparation Example 2 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (19 mg, 51%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09447044B2
Source datasetuspto-grants-2016_09
ORD IDord-46d8dd121b6d408cab4191cbe4855496
Source noteuspto-grants-2016_09