HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Bromo-3-(4-methanesulfonyl-phenyl)-imidazo[1,2-a]pyridine → 6-[2-(4-Fluoro-phenyl)-2H-pyrazol-3-yl]-3-(4-methanesulfonyl-phenyl)-imidazo[1,2-a]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Bromo-3-(4-methanesulfonyl-phenyl)-imidazo[1,2-a]pyridine | HCID 90189242 | — |
| Reactant | 1-(4-fluorophenyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole | HCID 90189368 | — |
| Product | 6-[2-(4-Fluoro-phenyl)-2H-pyrazol-3-yl]-3-(4-methanesulfonyl-phenyl)-imidazo[1,2-a]pyridine | HCID 76072430 | — |
Reaction Steps
The title compound, white solid (79 mg, 64%), MS (ISP) m/z=433.6 [(M+H)+], mp 226° C., was prepared in accordance with the general method of example 1 from 6-bromo-3-(4-methanesulfonyl-phenyl)-imidazo[1,2-a]pyridine (intermediate O) (0.1 g, 0.285 mmol) and 1-(4-fluoro-phenyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (intermediate A) (0.11 mg, 0.37 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09315502B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-a17a37a260524c769c33d69ac658e89c |
| Source note | uspto-grants-2016_04 |