6-Bromo-3-(4-fluorophenyl)-imidazo[1,2-a]pyridine → 3-(4-Fluoro-phenyl)-6-[2-(4-trifluoromethyl-phenyl)-2H-pyrazol-3-yl]-imidazo[1,2-a]pyridine

Participants

Reaction Steps

The title compound, white solid (37 mg, 26%), MS (ISP) m/z=423.6 [(M+H)+], mp 147° C., was prepared in accordance with the general method of example 1 from 6-bromo-3-(4-fluoro-phenyl)-imidazo[1,2-a]pyridine (intermediate E) (0.1 mg, 0.34 mmol) and 5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1-(4-trifluoromethyl-phenyl)-1H-pyrazole (intermediate P) (0.15 g, 0.45 mmol).

Provenance & Evidence