4-(6-Bromoimidazo[1,2-a]pyridin-3-yl)benzonitrile → 4-{6-[2-(4-Trifluoromethyl-phenyl)-2H-pyrazol-3-yl]-imidazo [1,2-a]pyridin-3-yl}-benzonitrile

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Reaction Steps

The title compound, off-white solid (59 mg, 41%), MS (ISP) m/z=430.6 [(M+H)+], mp 201° C., was prepared in accordance with the general method of example 1 from 4-(6-bromo-imidazo[1,2-a]pyridin-3-yl)-benzonitrile (intermediate N) (0.1 g, 0.335 mmol) and 5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1-(4-trifluoromethyl-phenyl)-1H-pyrazole (intermediate P) (0.15 g, 0.44 mmol).

Provenance & Evidence