Ethyl 3-(3,5-difluoro-4-hydroxyphenyl)propanoate → 3-[4-(2-Cyclopropylmethylsulfanyl-pyridin-3-ylmethoxy)-3,5-difluoro-phenyl]-propionic acid ethyl ester

Participants

Reaction Steps

3-Chloromethyl-2-cyclopropylmethylsulfanyl-pyridine (0.07 g, 0.32 mmol) obtained in Step C of Preparation Example 18 and 3-(3,5-difluoro-4-hydroxy-phenyl)-propionic acid ethyl ester obtained in Step D of Preparation Example 2 were reacted in the same manner as in Step A of Example 1 to obtain the title compound (0.1 g, 80%).

Provenance & Evidence