反应详情

温度

70 °C

To a solution of 4-bromo-2-hydroxybenzoic acid (15.0 g) in methanol (150 mL) was added dropwise thionyl chloride (10.1 mL) under ice-cooling, and the mixture was stirred overnight at 70° C. under argon atmosphere. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (14.2 g).

1. temperaturecooling
2. concentrationThe reaction mixture was concentrated under reduced pressure
3. customthe residue was purified by silica gel column chromatography (ethyl acetate/hexane)