HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 2-(3,5-difluoro-4-hydroxyphenyl)cyclopropanecarboxylate → 2-[4-(2-Cyclobutylsulfanyl-pyridin-3-ylmethoxy)-3,5-difluoro-phenyl]-cyclopropane carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 2-(3,5-difluoro-4-hydroxyphenyl)cyclopropanecarboxylate | HCID 59419842 | — |
| Reactant | 3-Chloromethyl-2-cyclopentylsulfanyl-6-methyl-pyridine | HCID 90118041 | — |
| Product | 2-[4-(2-Cyclobutylsulfanyl-pyridin-3-ylmethoxy)-3,5-difluoro-phenyl]-cyclopropane carboxylic acid | HCID 74222530 | 81.4% |
Reaction Steps
3-Chloromethyl-2-cyclobutylsulfanyl-pyridine (0.024 g, 0.113 mmol) obtained in Step C of Preparation Example 23 and 2-(3,5-difluoro-4-hydroxy-phenyl)-cyclopropane carboxylic acid ethyl ester (0.026 g, 0.113 mmol) obtained in Step B of Preparation Example 31 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (0.036 g, 81%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09447044B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-78756920ade84c9f9652a87795358fcd |
| Source note | uspto-grants-2016_09 |