HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → (2-fluoro-4-(1H-pyrazol-1-yl)phenyl)methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Reactant | methyl 2-fluoro-4-(1H-pyrazol-1-yl)benzoate | HCID 118468121 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (2-fluoro-4-(1H-pyrazol-1-yl)phenyl)methanol | HCID 59028616 | 91.4% |
Reaction Steps
To a solution of lithium aluminium hydride (0.16 g) in THF (5.50 mL) was added a solution of methyl 2-fluoro-4-(1H-pyrazol-1-yl)benzoate (0.89 g) in THF (5.50 mL) under ice-cooling, and the mixture was stirred for 1 hr. To the reaction solution was added water, the insoluble substance was removed by filtration, and the filtrate was concentrated under reduced pressure to give the title compound (0.71 g) as a crude product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09315458B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-0ca73cf487f0421a9fdfd3b7429e8ba9 |
| Source note | uspto-grants-2016_04 |