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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 629407Generated: October 30, 2026

Water → (2-fluoro-4-(1H-pyrazol-1-yl)phenyl)methanol

https://huagongshe.com/reaction/629407

Reaction equation

Participants

RoleNameHCIDCharge
ReactantWaterHCID 962—
ReactantAluminium lithium hydrideHCID 21226445—
Reactantmethyl 2-fluoro-4-(1H-pyrazol-1-yl)benzoateHCID 118468121—
SolventTetrahydrofuranHCID 8028—
Product(2-fluoro-4-(1H-pyrazol-1-yl)phenyl)methanolHCID 5902861691.4%

Reaction Steps

To a solution of lithium aluminium hydride (0.16 g) in THF (5.50 mL) was added a solution of methyl 2-fluoro-4-(1H-pyrazol-1-yl)benzoate (0.89 g) in THF (5.50 mL) under ice-cooling, and the mixture was stirred for 1 hr. To the reaction solution was added water, the insoluble substance was removed by filtration, and the filtrate was concentrated under reduced pressure to give the title compound (0.71 g) as a crude product.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09315458B2
Source datasetuspto-grants-2016_04
ORD IDord-0ca73cf487f0421a9fdfd3b7429e8ba9
Source noteuspto-grants-2016_04