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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 62942Generated: October 25, 2026

HCID 59419852, compound → 3-[3,5-Difluoro-4-(2-propylsulfanyl-pyridin-3-ylmethoxy)-phenyl]-2-methyl-propionic acid

https://huagongshe.com/reaction/62942

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 59419852HCID 59419852—
Reactant3-Chloromethyl-2-propylsulfanyl-pyridineHCID 90118282—
Product3-[3,5-Difluoro-4-(2-propylsulfanyl-pyridin-3-ylmethoxy)-phenyl]-2-methyl-propionic acidHCID 9011825069.9%

Reaction Steps

3-Chloromethyl-2-propylsulfanyl-pyridine (0.031 g, 0.15 mmol) obtained in Step C of Preparation Example 14 and 3-(3,5-difluoro-4-hydroxy-phenyl)-2-methyl-propionic acid ethyl ester (35 mg, 0.15 mmol) obtained in Step B of Preparation Example 34 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (0.04 g, 68%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09447044B2
Source datasetuspto-grants-2016_09
ORD IDord-0d2b4a27bf1d42b5bd93f5e2c324c17a
Source noteuspto-grants-2016_09