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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 62943Generated: October 30, 2026

HCID 59419852, compound → 3-[4-(2-Cyclobutylsulfanyl-pyridin-3-ylmethoxy)-3,5-difluoro-phenyl]-2-methyl-propionic acid

https://huagongshe.com/reaction/62943

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 59419852HCID 59419852—
Reactant3-Chloromethyl-2-cyclobutylsulfanyl-pyridineHCID 90118263—
Product3-[4-(2-Cyclobutylsulfanyl-pyridin-3-ylmethoxy)-3,5-difluoro-phenyl]-2-methyl-propionic acidHCID 9011839731.5%

Reaction Steps

3-Chloromethyl-2-cyclobutylsulfanyl-pyridine (0.045 g, 0.21 mmol) obtained in Step C of Preparation Example 23 and 3-(3,5-difluoro-4-hydroxy-phenyl)-2-methyl-propionic acid ethyl ester (49 mg, 0.21 mmol) obtained in Step B of Preparation Example 34 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (0.026 g, 31%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09447044B2
Source datasetuspto-grants-2016_09
ORD IDord-e752fe843abe40fa9c739f4fff49a7c7
Source noteuspto-grants-2016_09