HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 59419852, compound → 3-[4-(2-Cyclobutylsulfanyl-pyridin-3-ylmethoxy)-3,5-difluoro-phenyl]-2-methyl-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 59419852 | HCID 59419852 | — |
| Reactant | 3-Chloromethyl-2-cyclobutylsulfanyl-pyridine | HCID 90118263 | — |
| Product | 3-[4-(2-Cyclobutylsulfanyl-pyridin-3-ylmethoxy)-3,5-difluoro-phenyl]-2-methyl-propionic acid | HCID 90118397 | 31.5% |
Reaction Steps
3-Chloromethyl-2-cyclobutylsulfanyl-pyridine (0.045 g, 0.21 mmol) obtained in Step C of Preparation Example 23 and 3-(3,5-difluoro-4-hydroxy-phenyl)-2-methyl-propionic acid ethyl ester (49 mg, 0.21 mmol) obtained in Step B of Preparation Example 34 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (0.026 g, 31%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09447044B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-e752fe843abe40fa9c739f4fff49a7c7 |
| Source note | uspto-grants-2016_09 |