Ethyl 3-(4-hydroxy-3-methoxyphenyl)propionate → 3-[4-(2-Isopropylsulfanyl-pyridin-3-ylmethoxy)-3-methoxy-phenyl]-propionic acid

Participants

Reaction Steps

3-Chloromethyl-2-isopropylsulfanyl-pyridine (33 mg, 0.16 mmol) obtained in Step C of Preparation Example 1 and 3-(4-hydroxy-3-methoxy-phenyl]-propionic acid ethyl ester (40 mg, 0.17 mmol) obtained in Step C of Preparation Example 38 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (34 mg, 72%).

Provenance & Evidence