化工社化工社 化学情報印刷レポート · 研究参考用
Ethyl 3-(4-hydroxy-3-methoxyphenyl)propionate → 3-[4-(2-Cyclopentylsulfanyl-pyridin-3-ylmethoxy)-3-methoxy-phenyl]-propionic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl 3-(4-hydroxy-3-methoxyphenyl)propionate | HCID 123548 | — |
| 反応物 | 3-Chloromethyl-2-cyclopentylsulfanyl-pyridine | HCID 90118283 | — |
| 生成物 | 3-[4-(2-Cyclopentylsulfanyl-pyridin-3-ylmethoxy)-3-methoxy-phenyl]-propionic acid | HCID 90118093 | 64% |
反応手順
3-Chloromethyl-2-cyclopentylsulfanyl-pyridine (40 mg, 0.16 mmol) obtained in Step C of Preparation Example 8 and 3-(4-hydroxy-3-methoxy-phenyl]-propionic acid ethyl ester (48 mg, 0.21 mmol) obtained in Step C of Preparation Example 38 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (36 mg, 64%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09447044B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-b72c6d93c1ec47c18b87ff3479e2b396 |
| 出典メモ | uspto-grants-2016_09 |