Ethyl 2-(3,5-difluoro-4-hydroxyphenyl)cyclopropanecarboxylate → 2-[4-(2-Cyclopentylsulfanyl-pyridin-3-ylmethoxy)-3,5-difluoro-phenyl]-cyclopropane carboxylic acid

Participants

Reaction Steps

3-Chloromethyl-2-cyclopentylsulfanyl-pyridine (0.030 g, 0.13 mmol) obtained in Step C of Preparation Example 8 and 2-(3,5-difluoro-4-hydroxy-phenyl)-cyclopropane carboxylic acid ethyl ester (0.032 g, 0.13 mmol) obtained in Step B of Preparation Example 31 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (0.054 g, 99%).

Provenance & Evidence