3-(4-Hydroxyphenyl)-2,2-dimethylpropanoic acid ethyl ester → 3-[4-(6-Isopropylsulfanyl-pyridin-2-ylmethoxy)-phenyl]-2,2-dimethyl-propionic acid

Participants

Reaction Steps

2-Chloromethyl-6-isopropylsulfanyl-pyridine (0.02 g, 0.099 mmol) obtained in Step C of Preparation Example 16 and 3-(4-hydroxy-phenyl)-2,2-dimethyl-propionic acid ethyl ester (0.022 g, 0.099 mmol) obtained in Step D of Preparation Example 39 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (0.029 g, 81%).

Provenance & Evidence