Hydrochloric Acid → HCID 71542579, compound

Participants

Reaction Steps

A suspension of 2-(4-(adamantan-1-yl)phenoxy)-1-(4-methylpiperazin-1-yl)ethanone (0.4 g, 1.08 mmol), prepared from example 3, and 1.0 M HCl solution in diethyl ether (0.047 g, 1.30 mmol) in diethyl ether (4 mL) was stirred at room temperature overnight. The reaction mixture was filtered and dried in vacuum to afford a 4-(2-(4-(adamantan-1-yl)phenoxy)acetyl)-1-methylpiperazin-1-ium chloride as a crystalline white solid (0.43 g, 97.9% yield).

Provenance & Evidence