Methyl iodide → HCID 71542580, compound

HRID 629531Notes

Reaction equation

HRID 629531 reaction equation
[C:1]12([C:11]3[CH:27]=[CH:26][C:14]([O:15][CH2:16][C:17]([N:19]4[CH2:24][CH2:23][N:22]([CH3:25])[CH2:21][CH2:20]4)=[O:18])=[CH:13][CH:12]=3)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.[CH3:28][I:29]>C(OCC)C>[I-:29].[C:1]12([C:11]3[CH:27]=[CH:26][C:14]([O:15][CH2:16][C:17]([N:19]4[CH2:24][CH2:23][N+:22]([CH3:28])([CH3:25])[CH2:21][CH2:20]4)=[O:18])=[CH:13][CH:12]=3)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 71542096IDF-11774

Product 1

HCID 71542580HCID 71542580, compoundYield 105.8%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A suspension of 2-(4-(Adamantan-1-yl)phenoxy)-1-(4-methylpiperazin-1-yl)ethanone (0.2 g, 0.50 mmol), prepared from example 3, and methyl iodide (0.286 g, 2.01 mmol) in diethyl ether (2 mL) was stirred at room temperature overnight. The reaction mixture was filtered and dried in vacuum oven at 50° C. to afford a 4-(2-(4-(adamantan-1-yl)phenoxy)acetyl)-1,1-dimethylpiperazin-1-ium iodide as a white solid (0.27 g, 97.5% yield).

Workup

  1. filtrationThe reaction mixture was filtered
  2. customdried in vacuum oven at 50° C.

Sources & evidence

ORD record
ord-b2dbe4028d3c4d7bba163ffd4cc0d439
Source dataset
uspto-grants-2016_04
Patent number
US09315507B2

Reaction notes

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