1-(2-Hydroxyethyl)piperazine → HCID 71542394, compound

HRID 629544Notes

Reaction equation

HRID 629544 reaction equation
[C:1]12([C:11]3[CH:21]=[CH:20][C:14]([O:15][CH2:16][C:17](O)=[O:18])=[CH:13][CH:12]=3)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.[N:22]1([CH2:28][CH2:29][OH:30])[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1>>[C:1]12([C:11]3[CH:12]=[CH:13][C:14]([O:15][CH2:16][C:17]([N:25]4[CH2:26][CH2:27][N:22]([CH2:28][CH2:29][OH:30])[CH2:23][CH2:24]4)=[O:18])=[CH:20][CH:21]=3)[CH2:2][CH:3]3[CH2:9][CH:7]([CH2:6][CH:5]([CH2:4]3)[CH2:10]1)[CH2:8]2

Participants

3

Reactant 2

HCID 76771-(2-Hydroxyethyl)piperazineHCID 625381PMID26882240-Compound-8

Product 1

HCID 71542394HCID 71542394, compoundYield 90.3%

Procedure

The title compound was prepared from 2-(4-(adamantan-1-yl)phenoxy)acetic acid (0.15 g, 0.52 mmol) and 2-(piperazin-1-yl)ethanol (0.068 g, 0.52 mmol) according to the example 1, which was given 2-(4-(adamantan-1-yl)phenoxy)-1-(4-(2-hydroxyethyl)piperazin-1-yl)ethanone as a white solid (0.187 g, 90.3% yield).

Sources & evidence

ORD record
ord-8a35dbadbc224dad9d51ac6596ef083e
Source dataset
uspto-grants-2016_04
Patent number
US09315507B2

Reaction notes

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