HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloromethyl-2-isopropylsulfanyl-pyridine → 3-[3-Chloro-4-(2-isopropylsulfanyl-pyridin-3-ylmethoxy)-phenyl]-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloromethyl-2-isopropylsulfanyl-pyridine | HCID 53816681 | — |
| Reactant | Ethyl 3-(3-chloro-4-hydroxyphenyl)propanoate | HCID 68766162 | — |
| Product | 3-[3-Chloro-4-(2-isopropylsulfanyl-pyridin-3-ylmethoxy)-phenyl]-propionic acid | HCID 90118020 | 101.9% |
Reaction Steps
3-Chloromethyl-2-isopropylsulfanyl-pyridine (23 mg, 0.11 mmol) obtained in Step C of Preparation Example 1 and 3-(3-chloro-4-hydroxy-phenyl)-propionic acid ethyl ester (29 mg, 0.12 mmol) obtained in Step C of Preparation Example 42 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (41 mg, 93%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09447044B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-f68cf79ade48461d92f3c5d029fa5684 |
| Source note | uspto-grants-2016_09 |