PMID26882240-Compound-8 → HCID 71542490, compound

HRID 629550Notes

Reaction equation

HRID 629550 reaction equation
[C:1]12([C:11]3[CH:21]=[CH:20][C:14]([O:15][CH2:16][C:17](O)=[O:18])=[CH:13][CH:12]=3)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.O.[NH2:23][C:24]12[CH2:33][CH:28]3[CH2:29][CH:30]([CH2:32][C:26]([OH:34])([CH2:27]3)[CH2:25]1)[CH2:31]2>>[C:1]12([C:11]3[CH:21]=[CH:20][C:14]([O:15][CH2:16][C:17]([NH:23][C:24]45[CH2:33][CH:28]6[CH2:29][CH:30]([CH2:32][C:26]([OH:34])([CH2:27]6)[CH2:25]4)[CH2:31]5)=[O:18])=[CH:13][CH:12]=3)[CH2:2][CH:3]3[CH2:9][CH:7]([CH2:6][CH:5]([CH2:4]3)[CH2:10]1)[CH2:8]2

Participants

3

Reactant 2

HCID 625381PMID26882240-Compound-8HCID 70701233HCID 70701233, compound

Product 1

HCID 71542490HCID 71542490, compoundYield 91.5%

Procedure

The title compound was prepared from 2-(4-(adamantan-1-yl)phenoxy)acetic acid (0.2 g, 0.69 mmol) and 3-aminoadamantan-1-ol hydrate (0.129 g, 0.69 mmol) according to the example 1, which was given 2-(4-(adamantan-1-yl)phenoxy)-N-(3-hydroxyadamantan-1-yl)acetamide as a white solid (0.275 g, 90.4% yield).

Sources & evidence

ORD record
ord-5fdddc32d3e04e1ead1853f9d312ec21
Source dataset
uspto-grants-2016_04
Patent number
US09315507B2

Reaction notes

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