Ethyl 3-(3-chloro-4-hydroxyphenyl)propanoate → 3-[3-Chloro-4-(2-cyclopentylsulfanyl-pyridin-3-ylmethoxy)-phenyl]-propionic acid

HRID 62956Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 62956
Cl[CH2:2][C:3]1[C:4]([S:9][CH:10]2[CH2:14][CH2:13][CH2:12][CH2:11]2)=[N:5][CH:6]=[CH:7][CH:8]=1.C([O:17][C:18](=[O:29])[CH2:19][CH2:20][C:21]1[CH:26]=[CH:25][C:24]([OH:27])=[C:23]([Cl:28])[CH:22]=1)C>>[Cl:28][C:23]1[CH:22]=[C:21]([CH2:20][CH2:19][C:18]([OH:29])=[O:17])[CH:26]=[CH:25][C:24]=1[O:27][CH2:2][C:3]1[C:4]([S:9][CH:10]2[CH2:14][CH2:13][CH2:12][CH2:11]2)=[N:5][CH:6]=[CH:7][CH:8]=1

Komponenten

3

Edukt 2

HCID 68766162Ethyl 3-(3-chloro-4-hydroxyphenyl)propanoateHCID 901182833-Chloromethyl-2-cyclopentylsulfanyl-pyridine

Produkt 1

HCID 742227903-[3-Chloro-4-(2-cyclopentylsulfanyl-pyridin-3-ylmethoxy)-phenyl]-propionic acidAusbeute 91 %

Versuchsvorschrift

3-Chloromethyl-2-cyclopentylsulfanyl-pyridine (28 mg, 0.13 mmol) obtained in Step C of Preparation Example 8 and 3-(3-chloro-4-hydroxy-phenyl)-propionic acid ethyl ester (33 mg, 0.14 mmol) obtained in Step C of Preparation Example 42 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (41 mg, 91%).

Aufarbeitung

  1. customto react sequentially in the same manner as in Steps A and B of Example 1

Quellen und Nachweise

ORD-Eintrag
ord-00ce2801e7754971a5f55af645546dac
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09447044B2

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