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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 62957Generated: October 26, 2026

3-Chloromethyl-2-isopropylsulfanyl-pyridine → 3-[4-(2-Isopropylsulfanyl-pyridin-3-ylmethoxy)-2,3-dimethyl-phenyl]-propionic acid

https://huagongshe.com/reaction/62957

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Chloromethyl-2-isopropylsulfanyl-pyridineHCID 53816681—
ReactantEthyl 3-(4-hydroxy-2,3-dimethylphenyl)propanoateHCID 58566491—
Product3-[4-(2-Isopropylsulfanyl-pyridin-3-ylmethoxy)-2,3-dimethyl-phenyl]-propionic acidHCID 7422279185%

Reaction Steps

3-Chloromethyl-2-isopropylsulfanyl-pyridine (25 mg, 0.12 mmol) obtained in Step C of Preparation Example 1 and 3-(4-hydroxy-2,3-dimethyl-phenyl)-propionic acid ethyl ester (30 mg, 0.13 mmol) obtained in Step D of Preparation Example 43 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (34 mg, 85%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09447044B2
Source datasetuspto-grants-2016_09
ORD IDord-517aa0c5adbe49ac88824eeeb0b5af96
Source noteuspto-grants-2016_09