HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloromethyl-2-isopropylsulfanyl-pyridine → 3-[4-(2-Isopropylsulfanyl-pyridin-3-ylmethoxy)-2,3-dimethyl-phenyl]-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloromethyl-2-isopropylsulfanyl-pyridine | HCID 53816681 | — |
| Reactant | Ethyl 3-(4-hydroxy-2,3-dimethylphenyl)propanoate | HCID 58566491 | — |
| Product | 3-[4-(2-Isopropylsulfanyl-pyridin-3-ylmethoxy)-2,3-dimethyl-phenyl]-propionic acid | HCID 74222791 | 85% |
Reaction Steps
3-Chloromethyl-2-isopropylsulfanyl-pyridine (25 mg, 0.12 mmol) obtained in Step C of Preparation Example 1 and 3-(4-hydroxy-2,3-dimethyl-phenyl)-propionic acid ethyl ester (30 mg, 0.13 mmol) obtained in Step D of Preparation Example 43 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (34 mg, 85%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09447044B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-517aa0c5adbe49ac88824eeeb0b5af96 |
| Source note | uspto-grants-2016_09 |