HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → Methyl 2-(benzylamino)-4-fluorobenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Benzaldehyde | HCID 240 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | Methyl 2-amino-4-fluorobenzoate | HCID 14075433 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Methyl 2-(benzylamino)-4-fluorobenzoate | HCID 43735197 | — |
Reaction Steps
Methyl 2-amino-4-fluorobenzoate (0.90 g), benzaldehyde (0.54 mL), sodium triacetoxyborohydride (1.58 g) and acetic acid (0.3 mL) in CH2Cl2 (20 mL) were stirred for 3 hours. The reaction was quenched with methanol, concentrated, and chromatographed on silica gel with 5% ethyl acetate/hexanes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09315488B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-9d13b4f008cf464eb953ea563537eb85 |
| Source note | uspto-grants-2016_04 |