HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aniline → HCID 67227354, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aniline | HCID 6115 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Binap, (A+-)- | HCID 634876 | — |
| Reactant | Methyl 2-bromo-4-fluorobenzoate | HCID 7210837 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 67227354 | HCID 67227354 | — |
Reaction Steps
Methyl 2-bromo-4-fluorobenzoate (1.00 g), aniline (0.47 mL), palladium(II) acetate (0.048 g), 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (0.214 g) and Cs2CO3 (2.08 g) in toluene (12 mL) were stirred at 90° C. for 24 hours. The reaction was concentrated and chromatographed on silica gel with 5-50% ethyl acetate/hexanes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09315488B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-c9433f89de6247f1954cbb903133b405 |
| Source note | uspto-grants-2016_04 |