참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 4-Chloro-3-nitrobenzenesulfonamide | HCID 7324 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 1,4-Dioxane | HCID 31275 | — |
| 반응물 | 1-(2,2,2-Trifluoroethyl)piperidin-4-amine hydrochloride | HCID 17840002 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | HCID 67169936 | HCID 67169936 | — |
반응 단계
4-chloro-3-nitrobenzenesulfonamide (1.300 g), 1-(2,2,2-trifluoroethyl)piperidin-4-amine hydrochloride (1.201 g), and triethylamine (2.30 mL) were added to 1,4-dioxane (50 mL) and water (5 mL) and heated at 90° C. for 16 hours. The solution was concentrated on vacuum and purified by flash column chromatography on silica gel with ethyl acetate increasing to 5% methanol in ethyl acetate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09315488B2 |
|---|
| 출처 데이터셋 | uspto-grants-2016_04 |
|---|
| ORD ID | ord-4d8dfaec5d994dde899ab64ced3119bb |
|---|
| 출처 메모 | uspto-grants-2016_04 |
|---|
