참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4-Chlorophenylboronic acid | HCID 74299 | — |
| 반응물 | 4-bromo-1-methyl-1H-pyrazole-5-carbaldehyde | HCID 2794634 | — |
| 촉매 | Tetrabutylammonium Bromide | HCID 74236 | — |
| 촉매 | palladium(II) acetate | HCID 167845 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 4-(4-chlorophenyl)-1-methyl-1H-pyrazole-5-carbaldehyde | HCID 86642504 | — |
반응 단계
4-Bromo-1-methyl-1H-pyrazole-5-carbaldehyde (0.500 g), 4-chlorophenylboronic acid (0.455 g), tetrabutylammonium bromide (0.853 g), potassium carbonate (0.914 g) and palladium acetate (0.030 g) were stirred together in 5 mL of water and heated to 45° C. After stirring for 2.5 hours, the reaction was diluted with ethyl acetate (75 mL) and washed with water (25 mL), brine (50 mL), dried over magnesium sulfate, filtered and concentrated to give the crude material. The solid was chromatographed over silica gel (SF40-80) eluted using a gradient of 5% to 25% ethyl acetate/hexanes over 30 minutes.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09315488B2 |
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| 출처 데이터셋 | uspto-grants-2016_04 |
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| ORD ID | ord-138fb0dd8ec74fda8a2d54c40a9312d7 |
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| 출처 메모 | uspto-grants-2016_04 |
|---|
