HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → 3-cyano-4-((tetrahydro-2H-pyran-4-yl)methylamino)benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 4-Aminomethyltetrahydropyran | HCID 2773210 | — |
| Reactant | 3-Cyano-4-fluorobenzene-1-sulfonamide | HCID 25139897 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 3-cyano-4-((tetrahydro-2H-pyran-4-yl)methylamino)benzenesulfonamide | HCID 67126501 | — |
Reaction Steps
3-Cyano-4-fluorobenzenesulfonamide (500 mg), (tetrahydropyran-4-yl)methylamine (288 mg), and N,N-diisopropylethylamine (1.3 mL) were heated at 80° C. in tetrahydrofuran (15 mL) overnight. The mixture was diluted with ethyl acetate, washed with NaHCO3 solution and brine, and dried (Na2SO4), filtered and concentrated. The product was triturated from ethyl acetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09315488B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-66a5c80015804c98a48bf64d60b76687 |
| Source note | uspto-grants-2016_04 |