Morpholine → 4-Morpholinobut-2-YN-1-OL

HRID 629637Notes

Reaction equation

HRID 629637 reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.Cl[CH2:8][C:9]#[C:10][CH2:11][OH:12]>C1(C)C=CC=CC=1>[O:4]1[CH2:5][CH2:6][N:1]([CH2:8][C:9]#[C:10][CH2:11][OH:12])[CH2:2][CH2:3]1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 2027752-Butyn-1-ol, 4-chloro-

Product 1

HCID 31128494-Morpholinobut-2-YN-1-OL

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent2×

Conditions

Temperature
85 °C

Procedure

To a mixture of morpholine (4.36 g) in toluene (15 mL) was added 4-chlorobut-2-yn-1-ol (2.09 g) in toluene (5 mL). The mixture was stirred at 85° C. for three hours. After cooling, the solid was filtered off. The filtrate was subjected to vacuum distillation to give the title compound.

Workup

  1. temperatureAfter cooling
  2. filtrationthe solid was filtered off
  3. distillationThe filtrate was subjected to vacuum distillation

Sources & evidence

ORD record
ord-288300dd95a340d1afcedb61e552b5e3
Source dataset
uspto-grants-2016_04
Patent number
US09315488B2

Reaction notes

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