HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → (4-Fluorotetrahydro-2h-pyran-4-yl)methyl methanesulfonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | (4-Fluorooxan-4-yl)methanol | HCID 56971676 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (4-Fluorotetrahydro-2h-pyran-4-yl)methyl methanesulfonate | HCID 87279396 | — |
Reaction Steps
A mixture of EXAMPLE 306C (1.4 g), methanesulfonyl chloride (1.054 mL), triethylamine (2.99 mL), and 4-(dimethylamino)pyridine (0.051 g) in CH2Cl2 (20 mL) was stirred at 0° C. for 2 hours, concentrated and chromatographed on silica gel with 30% ethyl acetate in hexanes as eluent to give the product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09315488B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-d66cb95e312c44a8898be6c7b1d5d97f |
| Source note | uspto-grants-2016_04 |