反应详情

A mixture of EXAMPLE 409B (1.4 g) and hydrazine (1.548 mL) in ethanol (40 mL) was heated at 70° C. overnight, cooled to room temperature, slurried with CH2C12 (200 mL) and the solid removed by filtration. The filtrate was concentrated and chromatographed on silica gel with 100:5:1 ethyl acetate/methanol/NH4OH as eluent to give the product.

1. customthe solid removed by filtration
2. concentrationThe filtrate was concentrated
3. customchromatographed on silica gel with 100:5:1 ethyl acetate/methanol/NH4OH as eluent
4. customto give the product