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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 62966Generated: October 26, 2026

3-Chloromethyl-2-isopropylsulfanyl-pyridine → 2-[2-Chloro-4-(2-isopropylsulfanyl-pyridin-3-ylmethoxy)-phenyl]-cyclopropane carboxylic acid

https://huagongshe.com/reaction/62966

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Chloromethyl-2-isopropylsulfanyl-pyridineHCID 53816681—
Reactant2-(2-Chloro-4-hydroxy-phenyl)-cyclopropane carboxylic acid ethyl esterHCID 90118324—
Product2-[2-Chloro-4-(2-isopropylsulfanyl-pyridin-3-ylmethoxy)-phenyl]-cyclopropane carboxylic acidHCID 7422288555%

Reaction Steps

3-Chloromethyl-2-isopropylsulfanyl-pyridine (0.040 g, 0.20 mmol) obtained in Step C of Preparation Example 1 and 2-(2-chloro-4-hydroxy-phenyl)-cyclopropane carboxylic acid ethyl ester (0.047 g, 0.20 mmol) obtained in Step E of Preparation Example 45 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (0.041 g, 55%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09447044B2
Source datasetuspto-grants-2016_09
ORD IDord-f8259b1e0e4e4c34bed996fd33283a91
Source noteuspto-grants-2016_09