反应详情

温度

70 °C

2,3-dihydrobenzofuran (5 g, 41.6 mmol) was dissolved in 35 mL of acetic acid, and ¼ HNO3 (0.9 mL, 45.4 mmol) was added dropwise. At the beginning of reaction, it was heated to 70° C., then the residual HNO3 was added. After 0.5 hour, the reaction was cooled, added into ice-water, and then neutralized with Na2CO3. The water layer was extracted with ethyl acetate. The organic layers were combined and dried, concentrated under vacuum, purified by column chromatography to obtain a product (1 g, 14.6%).

1. customAt the beginning of reaction, it
2. temperaturethe reaction was cooled
3. extractionThe water layer was extracted with ethyl acetate
4. customdried
5. concentrationconcentrated under vacuum
6. custompurified by column chromatography