HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Nitro-2,3-dihydro-1-benzofuran → 2,3-Dihydro-1-benzofuran-5-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Nitro-2,3-dihydro-1-benzofuran | HCID 21816585 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2,3-Dihydro-1-benzofuran-5-amine | HCID 3841102 | 97.2% |
Reaction Steps
The product (1 g, 6.1 mmol) obtained in Step 1, Raney Ni (0.1 g) and MeOH (10 mL) were used for hydrogenation at room temperature and hydrogen pressure of 50 PSI, until the reaction was finished. The catalyst was removed by filtration, the fitrate was concentrated under vacuum to obtain a product (800 mg, 97.2%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09315513B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-055cbcadca7348308c60ac6daade59e0 |
| Source note | uspto-grants-2016_04 |