反应详情

温度

65 °C

2,3-Dihydrobenzofuran (36 g, 0.3 mol) was added to glacial acetic acid (100 mL), heated to 65° C., then concentrated nitric acid (25 mL, 0.36 mol) was added dropwise into the reaction solution, the temperature of the reaction solution was controlled at 65-75° C. After the end of dropwise addition, the agitation was kept for 0.5 h. It was then cooled to room temperature, filtered, washed with water, and dried to obtain a product (22 g, 44.4%).

1. customwas controlled at 65-75° C
2. additionAfter the end of dropwise addition
3. temperatureIt was then cooled to room temperature
4. filtrationfiltered
5. washwashed with water
6. customdried