Ethyl 3-(3-chloro-4-hydroxyphenyl)-2-methylpropanoate → 3-[3-Chloro-4-(2-cyclobutylsulfanyl-pyridin-3-ylmethoxy)-phenyl]-2-methyl-propionic acid

Participants

Reaction Steps

3-Chloromethyl-2-cyclobutylsulfanyl-pyridine (50 mg, 0.25 mmol) obtained in Step C of Preparation Example 23 and 3-(3-chloro-4-hydroxy-phenyl)-2-methyl-propionic acid ethyl ester (60 mg, 0.28 mmol) obtained in Step B of Preparation Example 46 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (76 mg, 81%).

Provenance & Evidence