Imidazole → HCID 131735381, compound

Participants

Reaction Steps

A solution of intermediate tert-butyl (2S,5R)-5-(hydroxymethyl)-2-[1-hydroxy-2-(2-nitrophenyl)ethyl]morpholine-4-carboxylate and imidazole (3.2 eq.) in dry DMF (0.43 M) was treated with neat TBDPS-Cl (1.1 eq.) and the final solution stirred at room temperature for 48 h, diluted with DCM and heptane (excess) and concentrated. The residue was purified by automated silicagel flash chromatography system eluted with a gradient 10% to 50% EtOAc in hexanes, to afford title compound as white foam.

Provenance & Evidence