Methanol → HCID 86726330, compound

Participants

Reaction Steps

A solution of intermediate tert-butyl (2S,5S)-5-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-[1-fluoro-2-(2-nitrophenyl)ethyl]morpholine-4-carboxylate (1 eq.) in a mixture 5:2:1 THF:MeOH:H2O (0.002 M) was warmed up to +59° C. and treated with solid iron (223 eq.). The mixture was further stirred at the same temperature for 45 min, diluted with DCM, washed with sat. NaHCO3, dried over MgSO4, filtered and concentrated. The product was submitted to the next step without further purification. Light yellow oil.

Provenance & Evidence