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HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 62975Erstellt: 25. Oktober 2026

2-Chloromethyl-6-cyclopentylsulfanyl-pyridine → 2-[3-Chloro-4-(6-cyclopentylsulfanyl-pyridin-2-ylmethoxy)-phenyl]-cyclopropane carboxylic acid

https://huagongshe.com/reaction/62975

Reaktionsgleichung

Beteiligte Stoffe

RolleNameHCIDEinwaage
Edukt2-Chloromethyl-6-cyclopentylsulfanyl-pyridineHCID 90118181—
Edukt2-(3-Chloro-4-hydroxy-phenyl)-cyclopropane carboxylic acid ethyl esterHCID 90118199—
Produkt2-[3-Chloro-4-(6-cyclopentylsulfanyl-pyridin-2-ylmethoxy)-phenyl]-cyclopropane carboxylic acidHCID 9011809672%

Reaktionsschritte

2-Chloromethyl-6-cyclopentylsulfanyl-pyridine (42 mg, 0.18 mmol) obtained in Step C of Preparation Example 27 and 2-(3-chloro-4-hydroxy-phenyl)-cyclopropane carboxylic acid ethyl ester (49 mg, 0.20 mmol) obtained in Step B of Preparation Example 47 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (47 mg, 72%).

Herkunft & Nachweise

DOI10.6084/m9.figshare.5104873.v1
PatentnummerUS09447044B2
Quelldatensatzuspto-grants-2016_09
ORD IDord-2b8501c18ed04efa99bee137888086f5
Quellennotizuspto-grants-2016_09