HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-Chloromethyl-6-cyclopentylsulfanyl-pyridine → 2-[3-Chloro-4-(6-cyclopentylsulfanyl-pyridin-2-ylmethoxy)-phenyl]-cyclopropane carboxylic acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-Chloromethyl-6-cyclopentylsulfanyl-pyridine | HCID 90118181 | — |
| Edukt | 2-(3-Chloro-4-hydroxy-phenyl)-cyclopropane carboxylic acid ethyl ester | HCID 90118199 | — |
| Produkt | 2-[3-Chloro-4-(6-cyclopentylsulfanyl-pyridin-2-ylmethoxy)-phenyl]-cyclopropane carboxylic acid | HCID 90118096 | 72% |
Reaktionsschritte
2-Chloromethyl-6-cyclopentylsulfanyl-pyridine (42 mg, 0.18 mmol) obtained in Step C of Preparation Example 27 and 2-(3-chloro-4-hydroxy-phenyl)-cyclopropane carboxylic acid ethyl ester (49 mg, 0.20 mmol) obtained in Step B of Preparation Example 47 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (47 mg, 72%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09447044B2 |
| Quelldatensatz | uspto-grants-2016_09 |
| ORD ID | ord-2b8501c18ed04efa99bee137888086f5 |
| Quellennotiz | uspto-grants-2016_09 |