2-(3-Chloro-4-hydroxy-phenyl)-cyclopropane carboxylic acid ethyl ester → 2-[3-Chloro-4-(2-cyclopentylsulfanyl-pyridin-3-ylmethoxy)-phenyl]-cyclopropane carboxylic acid

Participants

Reaction Steps

3-Chloromethyl-2-cyclopentylsulfanyl-pyridine (49 mg, 0.23 mmol) obtained in Step C of Preparation Example 8 and 2-(3-chloro-4-hydroxy-phenyl)-cyclopropane carboxylic acid ethyl ester (62 mg, 0.25 mmol) obtained in Step B of Preparation Example 47 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (65 mg, 75%).

Provenance & Evidence