1,4-Dioxane → Hydrochloric Acid

Participants

Reaction Steps

The product from step 3 (60 mg, 0.078 mmol) was dissolved in a solution of 4M HCl in dioxane (1 mL, 4 mmol) and the solution was stirred at ambient temperature for 1 h. The solvent was removed under reduced pressure and the residue was dried in vacuo for 12 h to give an HCl salt of the title compound as a solid. LCMS: RT=0.95 min (2 min gradient), MS (ES) m/z=674.6 (M+H)+.

Provenance & Evidence