HCID 86726370, compound → HCID 86726376, compound

HRID 629768Notes

Reaction equation

HRID 629768 reaction equation
[N:1]([C@@H:4]([C@@H:8]([C:19]1[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=1)[C:9]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[N:12]=[CH:11][CH:10]=1)[C:5](O)=[O:6])=[N+]=[N-].[NH2:26][C:27]1[CH:57]=[CH:56][CH:55]=[C:54]([F:58])[C:28]=1[CH2:29][CH2:30][C@H:31]1[O:36][CH2:35][C@@H:34]([CH2:37][O:38][C:39](=[O:46])[NH:40][CH2:41][C:42]([F:45])([F:44])[F:43])[N:33](C(OC(C)(C)C)=O)[CH2:32]1>>[F:44][C:42]([F:43])([F:45])[CH2:41][NH:40][C:39](=[O:46])[O:38][CH2:37][C@@H:34]1[CH2:35][O:36][C@H:31]([CH2:30][CH2:29][C:28]2[C:54]([F:58])=[CH:55][CH:56]=[CH:57][C:27]=2[NH:26][C:5](=[O:6])[C@H:4]([C@H:8]([C:9]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[N:12]=[CH:11][CH:10]=2)[C:19]2[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=2)[NH2:1])[CH2:32][NH:33]1

Participants

3

Reactant 2

HCID 86726370HCID 86726370, compoundHCID 86726377HCID 86726377, compound

Product 1

HCID 86726376HCID 86726376, compound

Procedure

The title compound was prepared from the product of step 1 and the product of step 4 of Example 99 using the procedures given in steps 2-4 of Example 93. MS (ES) m/z=688 (M+H)+.

Sources & evidence

ORD record
ord-64a44476cd584f849484cef69d6eed52
Source dataset
uspto-grants-2016_04
Patent number
US09315475B2

Reaction notes

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