Trimethylphosphine → HCID 86726381, compound

Participants

Reaction Steps

To a solution of the product from step 2 (80 mg, 0.102 mmol) in EtOAc (8 mL) and water (2 mL), was added trimethylphosphine (0.5 mL, 1M solution in THF, 0.5 mmol). The reaction mixture was stirred at ambient temperature for 2 h, then diluted with water (20 mL) and extracted with EtOAc (25 mL×3). The combined organic extracts were washed with brine (25 mL), dried (Na2SO4), filtered, and concentrated under reduced pressure to provide the title compound as colorless oil. This material was used in the next step without any additional purification. (M+H-Boc)+=682.

Provenance & Evidence