HCID 86726370, compound → HCID 86578198, compound

HRID 629777Notes

Reaction equation

[N:1]([C@@H:4]([C@H:8]([C:16]1[CH:24]=[CH:23][C:19]2[O:20][CH2:21][O:22][C:18]=2[CH:17]=1)[C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=1)[C:5](O)=[O:6])=[N+]=[N-].[NH2:25][C:26]1[CH:56]=[CH:55][CH:54]=[C:53]([F:57])[C:27]=1[CH2:28][CH2:29][C@H:30]1[O:35][CH2:34][C@@H:33]([CH2:36][O:37][C:38](=[O:45])[NH:39][CH2:40][C:41]([F:44])([F:43])[F:42])[N:32](C(OC(C)(C)C)=O)[CH2:31]1>>[O:20]1[C:19]2[CH:23]=[CH:24][C:16]([C@H:8]([C:9]3[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=3)[C@@H:4]([C:5]([NH:25][C:26]3[CH:56]=[CH:55][CH:54]=[C:53]([F:57])[C:27]=3[CH2:28][CH2:29][C@H:30]3[O:35][CH2:34][C@@H:33]([CH2:36][O:37][C:38](=[O:45])[NH:39][CH2:40][C:41]([F:43])([F:44])[F:42])[NH:32][CH2:31]3)=[O:6])[NH:1][C:21]([O:20][CH3:19])=[O:22])=[CH:17][C:18]=2[O:22][CH2:21]1

Participants

Reactant 2

HCID 86726370HCID 86726370, compound

HCID 86726380HCID 86726380, compound

Product 1

HCID 86578198HCID 86578198, compound

Procedure

The title compound was prepared from (2S,3S)-2-azido-3-(benzo[d][1,3]dioxol-5-yl)-3-(4-chlorophenyl)propanoic acid (Example 1010, step 1) and the product of step 4 of Example 99 using the procedures given in steps 2 and 3 of Example 93 and steps 1 and 2 of Example 91. MS (ES) m/z=739 (M+H)+.

Sources & evidence

ORD record: ord-4f26fa84c2124dca9cfd9a236183a381
Source dataset: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09315475B2

Reaction notes

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