HCID 86726370, compound → HCID 86578199, compound

HRID 629778Notes

Reaction equation

[N:1]([C@@H:4]([C@@H:8]([C:20]1[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[O:15][C:16]([F:19])([F:18])[F:17])[C:5](O)=[O:6])=[N+]=[N-].[NH2:27][C:28]1[CH:58]=[CH:57][CH:56]=[C:55]([F:59])[C:29]=1[CH2:30][CH2:31][C@H:32]1[O:37][CH2:36][C@@H:35]([CH2:38][O:39][C:40](=[O:47])[NH:41][CH2:42][C:43]([F:46])([F:45])[F:44])[N:34](C(OC(C)(C)C)=O)[CH2:33]1>>[F:26][C:23]1[CH:22]=[CH:21][C:20]([C@@H:8]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[O:15][C:16]([F:18])([F:19])[F:17])[C@@H:4]([C:5]([NH:27][C:28]2[CH:58]=[CH:57][CH:56]=[C:55]([F:59])[C:29]=2[CH2:30][CH2:31][C@H:32]2[O:37][CH2:36][C@@H:35]([CH2:38][O:39][C:40](=[O:47])[NH:41][CH2:42][C:43]([F:44])([F:46])[F:45])[NH:34][CH2:33]2)=[O:6])[NH:1][C:40]([O:39][CH3:38])=[O:47])=[CH:25][CH:24]=1

Participants

Reactant 2

HCID 86726370HCID 86726370, compound

HCID 90046674HCID 90046674, compound

Product 1

HCID 86578199HCID 86578199, compound

Procedure

The title compound was prepared from the product of step 1 and the product of step 4 of Example 99 using the procedures given in steps 2 and 3 of Example 93 and steps 1 and 2 of Example 91. MS (ES) m/z=763 (M+H)+.

Sources & evidence

ORD record: ord-fbccea2485b1400094c78ede35a1f7a1
Source dataset: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09315475B2

Reaction notes

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