(2S,5S)-tert-butyl 2-[(2-amino-6-fluorophenoxy)methyl]-5-[(carbamoyloxy)methyl]morpholine-4-carboxylate → methyl N-[(1S,2S)-1-[[2-[[(2S,5S)-5-(carbamoyloxymethyl)morpholin-2-yl]methoxy]-3-fluoro-phenyl]carbamoyl]-2-(3-fluorophenyl)-2-(4-fluorophenyl)ethyl]carbamate

Participants

Role	Name	HCID	Charge
Reactant	(2S,5S)-tert-butyl 2-[(2-amino-6-fluorophenoxy)methyl]-5-[(carbamoyloxy)methyl]morpholine-4-carboxylate	HCID 86726396	—
Reactant	(2S,3S)-2-Azido-3-(3-fluorophenyl)-3-(4-fluorophenyl)propanoic acid	HCID 86726397	—
Product	methyl N-[(1S,2S)-1-[[2-[[(2S,5S)-5-(carbamoyloxymethyl)morpholin-2-yl]methoxy]-3-fluoro-phenyl]carbamoyl]-2-(3-fluorophenyl)-2-(4-fluorophenyl)ethyl]carbamate	HCID 86578235	—

Reaction Steps

The title compound was prepared from the product of step 1 and the product of step 5 using the procedures given in steps 2-4 of Example 93. MS (ES) m/z=617 (M+H)+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09315475B2
Source dataset	uspto-grants-2016_04
ORD ID	ord-8ea4b68d962247c6a1245d334a635026
Source note	uspto-grants-2016_04