HCID 86726370, compound → HCID 86578307, compound

HRID 629788Notes

Reaction equation

HRID 629788 reaction equation
[N:1]([C@@H:4]([C@@H:8]([C:15]1[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=1)[CH:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1)[C:5]([OH:7])=O)=[N+]=[N-].[NH2:22][C:23]1[CH:53]=[CH:52][CH:51]=[C:50]([F:54])[C:24]=1[CH2:25][CH2:26][C@H:27]1[O:32][CH2:31][C@@H:30]([CH2:33][O:34][C:35](=[O:42])[NH:36][CH2:37][C:38]([F:41])([F:40])[F:39])[N:29](C(OC(C)(C)C)=O)[CH2:28]1>>[F:21][C:18]1[CH:19]=[CH:20][C:15]([C@@H:8]([CH:9]2[CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)[C@@H:4]([C:5]([NH:22][C:23]2[CH:53]=[CH:52][CH:51]=[C:50]([F:54])[C:24]=2[CH2:25][CH2:26][C@H:27]2[O:32][CH2:31][C@@H:30]([CH2:33][O:34][C:35](=[O:42])[NH:36][CH2:37][C:38]([F:41])([F:40])[F:39])[NH:29][CH2:28]2)=[O:7])[NH2:1])=[CH:16][CH:17]=1

Participants

3

Reactant 2

HCID 86726370HCID 86726370, compoundHCID 86726400HCID 86726400, compound

Product 1

HCID 86578307HCID 86578307, compound

Procedure

The title compound was prepared from (2S,3R)-2-azido-3-(4-fluorophenyl)-3-(tetrahydro-2H-pyran-4-yl)propanoic acid (Example 1033, step 1) and the product of step 4 of Example 99 using the procedures given in steps 2-4 of Example 93. MS (ES) m/z=629 (M+H)+.

Sources & evidence

ORD record
ord-c48d7a82c0e54666a5cd9997e6789408
Source dataset
uspto-grants-2016_04
Patent number
US09315475B2

Reaction notes

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